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Susceptibility pattern of E. coli-associated urinary tract infection (UTI): a comparison of spinal cord injury-related and nosocomial UTI [Article de Revue]

 
[Profil de résistance dans les infections urinaires à Escherichia coli : comparaison des infections urinaires liées à une lésion de la moëlle épinière et des infections urinaires nosocomiales]
Khorvash, Farzin ; MOSTAFAVIZADEH K ; Mobasherizadeh, S ; BEHJATI M
Medical science monitor. 2009/11; 15(11) : Cr579-CR582
Summary: BACKGROUND: Evolving resistant uropathogens are associated with elevated risk of morbidity and mortality both in nosocomial and in spinal cord injury (SCI)-associated urinary tract infections (UTIs). Clinico-epidemiological studies are therefore essential to facilitate empirical therapy and decrease treatment time. MATERIAL/METHODS: This study was performed at Al-Zahra Hospital, Isfahan University of Medical Sciences, Isfahan, Iran. All E. coli-infected UTI hospitalized patients, except those with symptoms of UTI prior to admission or in the first 48 hours of hospitalization, were included in this study as group A. All E. coli-infected SCI-associated UTIs were included in group B. Urine samples were cultured and the MICs of nine antibiotics on the isolated bacteria were determined by the gradient concentration method with E. coli ATCC25922 as the standard control. RESULTS: Antibiotic-resistant uropathogens were more prevalent among the nosocomial than the SCI-associated UTIs. The antibiotic-resistance rates of isolated E. coli in the nosocomial and SCI-associated UTIs were 13.9% and 5.9% for amikacin, 65% and 40.5% for ceftazidime, 69.8% and 32.4% for ceftriaxone, 50% and 41.2% for ciprofloxacin, 56.9% and 13.6% for gentamicine, 2.1% and 0% for imipenem, 3.9% and 0% for meropenem, and 73.6% and 63.6% for trimethoprim/sulfamethoxazole, respectively. Only resistance to nalidixic acid was mildly higher in SCI E. coli. The MIC50 of all the antibiotics except nalidixic acid was higher in nosocomial E. coli. CONCLUSIONS: Despite more risk factors for antibiotic-resistant E. coli in SCI patients, antibiotic-resistant E. coli was observed more in nosocomial UTIs, which may be attributable to the hospital environment.(RESUME D'AUTEUR)
Publication
2009/11

Pages
Cr579-CR582

Language
Anglais

Number of ref
12

Published in
Medical science monitor

ID notice
318764

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Hôpital Pellegrin - Bâtiment Le Tondu
33076 Bordeaux
Tél : 05.56.79.60.58
cclin.so@chu-bordeaux.fr
http://www.cclin-sudouest.com/

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