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The Treatment of Severe Group A Streptococcal Infections [Article de Revue]

 
[Le traitement des infections sévères au streptocoque groupe A]
NORRBY-TEGLUND ; RAGNAR NORRBY ; LOW
Current infectious diseases reports. 2003/01; 5(1) : 28-37
Summary: Les streptocoques groupe A sont responsables de maladies allant des infections superficielles non compliquées aux infections systématiques sévères associées à une morbidité et à une mortalité élevées. Depuis la fin des années 1980 il y a dans le monde entier une résurgence d'infections streptococciques invasives agressives comprenant le syndrôme du choc toxique streptococcique et la fasciite nécrosante qui présentent un taux de mortalité élevé. Cet article présente les aspects cliniques et la physiopathologie du sepsis, le traitement antibiotique et les nouvelles statégies thérapeutiques.

Group A streptococci can cause a variety of diseases ranging from uncomplicated superficial infections to severe systemic infections associated with high morbidity and mortality. Since the late 1980s a drastic resurgence of highly aggressive invasive streptococcal infections, including streptococcal toxic shock syndrome and necrotizing fasciitis, have been noted worldwide. This has prompted intense research in the field and important new information has been gained regarding the pathogenesis and treatment of life-threatening invasive group A streptococcal infections. Exotoxins with superantigenic activities have been identified as central mediators of the systemic effects seen in streptococcal toxic shock syndrome. Novel therapeutic strategies include agents that can inhibit these superantigens, and one promising candidate is intravenous polyspecific immunoglobulin that contains neutralizing antibodies against a wide spectrum of streptococcal superantigens.Intravenous immunoglobulin adjunctive therapy was shown in a case-control study to reduce mortality in patients with streptococcal toxic shock syndrome.
Publication
2003/01

Pages
28-37

Language
Anglais

Number of ref
71

Published in
Current infectious diseases reports

ID notice
318877

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