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Prevention of Cytomegalovirus disease in recipients of solid-organ transplants [Article de Revue]

 
[Prévention des infections à Cytomegalovirus chez les receveurs de greffe d'organes]
PAYA CV
Clinical infectious diseases. 2001/02/15; 32(4) : 596-603
Summary: Après greffe d.organe, des complications associées au cytomégalovirus (CMV) peuvent apparaître. De nouvelles méthodes de détection du CMV indiquent que des niveaux faibles de virus peuvent être présents chez beaucoup de patients asymptômatiques. Cette revue de la littérature rappellent les connaissances actuelles de la pathogénicité au CMV après transplantation et décrit différentes mesures préventives.

The introduction and combination of more-potent immunosuppressive regimens, and the increased transplantation of organs into more severely ill patients, have again placed cytomegalovirus (CMV) disease in the spotlight of posttransplantation complications. Both direct and associated complications related to CMV need to be considered in understanding the pathogenesis of CMV infection after solid-organ transplantation. New diagnostic methods with higher sensitivity for the detection of CMV and the ability to quantify CMV indicate that low levels of CMV replication are present in many patients who don't have clinical symptoms ascribed to CMV infection. How these low levels of CMV replication impact the outcome of the transplanted graft remains unknown. In addition, there needs to be further study regarding whether only patients at high risk for developing CMV disease or, also, those with clinically asymptomatic levels of CMV replication should be the target of effective preventive regimens. This review summarizes our current knowledge of the pathogenesis of CMV infection after solid-organ transplantation, and it outlines different effective preventive regimens and approaches.(RESUME D'AUTEUR)
Publication
, 2001/02/15

Pages
596-603

Language
Anglais

Number of ref
47

ID notice
318892

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CCLIN Est
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CCLIN Paris Nord
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CCLIN Sud-Est
CClin Sud-Est
Hospices Civils de Lyon
Hôpital Henry Gabriel
20 route de vourles
69230 Saint-Genis-Laval
Tél : 04.78.86.49.50
cclinse@chu-lyon.fr
http://cclin-sudest.chu-lyon.fr/
CCLIN Sud-Ouest
CClin Sud-Ouest
CHU de Bordeaux
Hôpital Pellegrin - Bâtiment Le Tondu
33076 Bordeaux
Tél : 05.56.79.60.58
cclin.so@chu-bordeaux.fr
http://www.cclin-sudouest.com/

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